Drug encyclopedia

Melipraminum (Imizinum, Imipraminum) falls into to strong antidepressants with a concomitant promoting effect.

Pharmacokinetics.
The drug is well absorbed at intake, reaches the maximum concentration in a blood in 1-2 h, after intramuscular introduction – in 30-60 minutes Hакапливается in a liver, nephroses, a brain. Well inpours through a blood-brain barrier. Communication with protein of 76-95 %. It is awakely metabolized in a liver, it is excreted with urine. An effective half-life 9-20hrs. Indications. Melipraminum apply at depressions of a various aetiology: astheno-depressions, endogenous depression at sick of a maniacally-depressive psychosis, a situational depression, depressions at psychopathies, neurosises, and also at an uracrasia.

Antidepressive action educes gradually, in 1-2 weeks. The melancholy, motorial block decreases, the mood is enriched, there is a vivacity, the mental and general tonus of an organism raises. In the absence of effect within 2-3 weeks a drug cancel. Course of treatment of 4-5 weeks.

Side effects.
At hypersensitivity or an overdosage intensifying or appearance of a sleeplessness, excitation, alarm, hallucinations, delirium is possible. A drug cancel and prescribe neuroleptics, at a sleeplessness – soporific. The headache, giddiness, a tremor, a sweating, a numbness of extremities, paresthesias, an itch, allergic responses, a leukocytosis, an eosinophilia in some cases become perceptible. In connection with cholinolytic action accomodation disturbance, an emiction delay, a tachycardia, dyspeptic distresses are possible dryness in a mouth.

Contraindications.
Acute diseases of a liver, nephroses, hemopoietic members, sugar diabetes, cardiovascular insufficiency, disturbances of conductivity of heart, infectious diseases, cerebral circulation disturbances, a glaucoma, a prostate gland adenoma, the urinary bladder atonia, the first trimester of pregnancy. At a peptic ulcer intake is contraindicative.

Amitriptyline (Triptizolum) also falls into to drugs with good bioavailability and high affinity to blood plasma protein. The effective half-life at healthy people compounds 24-48 h, and at patients it fluctuates from 9 till 24 o’clock. Therapeutic concentration of amitriptyline is peer a blood 0,04-0,16 mkg/ml.

The basic indication to application of antidepressants taking into account features of their pharmacodynamics are depressions. At the depressions accompanied by flabbiness, block, lack of initiative, apply Nialamidum of 50-70 mg/sut in the morning and in the afternoon.

The therapeutic effect occurs routinely in 1-2 weeks of method. Use Nialamidum also at an epileptiform neuralgia, a stenocardia. Interaction of inhibitors MAO with appreciable number of medicines, and also the products containing a tyramine (cheese, coffee, beer, wine, cream), with development of serious complications confines application of drugs of this bunch.

Amitriptyline prescribe under the same indications since 50-75 mg/days

Azaphenum apply at depressions light and moderately severe, including widely use in out-patient practice in a dose of 25-50 mg/sut with its gradual augmentation to 150-200 mg/days Azaphenum possesses weak soporific action and it is deprived unlike Imizinum and amitriptyline of cholinolytic activity in this connection it can be applied at patients with a glaucoma and a prostate adenoma, at persons of advanced age.

Pyrazidolum possesses properties of inhibitors MAO both 3 and 4-cyclic bonds. Apply it at maniacally-depressive psychoses, schizophrenia with affective distresses and other pathological states.