Antidepressants
Antidepressants unite to the big bunch of the medicines which basic property is depression elimination. To antidepressants carry inhibitors MAO: hydrazine (Iprazidum, Nialamidum) and not hydrazine derivatives (Indopanum etc.), 4 and 3-cyclic bonds (Imipraminum, amitriptyline, Azaphenum, Pyrazidolum), secondary aminoes (desipramine).
Excrete also bunch of antidepressants of II generation and lithium drugs.
Possible side effects: drowsiness, dryness in a mouth, “hymenium” before eyes, constipations, difficulties at an emiction, syncopes, a sweating, a shiver, an eruption, palpitation, a headache.
Caution: In a combination to some medicines and foodstuff inhibitors MAO have the opposite effect that can result in to appreciable lifting of arterial pressure.
At therapy by antidepressants of both bunches it is necessary to confine alcohol method. Take an interest at the doctor, whether it is possible to control at method of antidepressants the car or other mechanisms.
The additional information
Most and safe three ring compounds are studied. The mechanism of action three cyclic antidepressants is bound to blockage of return seizure of Noradrenalinum by presynaptic nerve terminations owing to what Noradrenalinum content in synaptic gaps is enlarged.
In places of accumulation of Noradrenalinum (various frames of a brain, and also heart and lungs, a spleen and other members) raises activity of adrenergic transfer of nervous impulses, descends excitation central and peripheric a – and b-adrenoretseptorov.
Similar action of 3-cyclic antidepressants is observed concerning Dofaminum and a serotonin. Drugs of this bunch quench central and peripheric M-holinoretseptory.
Inhibitors MAO quench Nialamidum, invoking an oxidative deamination and an inactivation of monoamines (Noradrenalinum, Dofaminum, a serotonin) with accumulation of these amines in brain frames.
Some antidepressants combine action of inhibitors MAO both 4 and 3-cyclic bonds. The general property of all antidepressants is action: influence on affective sphere with enriching of mood and the general mental state.