Halothanum
Halothanum (Ftorotanum, ftorotan, anestan, fluctan, Fluothane, halan, hаlothanum, narcotan, rhodialotan, somnothane) represents transparent and uncolored fluid with a boiling point 50.2°С. Easily escapes, reminds Chloroformium odour, with sweet and stinging taste.
Halothanum - one of several halogen of the keeping anaesthetics synthesised between 1950 and 1955 years. Now Halothanum, obviously, one of anaesthetics most widely applied all over the world though last decade its application has seriously dropped in the educed countries in connection with a problem of a hepatotoxic and appearance of new, more modern drugs.
It is prescribed in inhalations; it is applied to intensifying of action and maintenance of all kinds of an anaesthesia during carrying out of surgical operations.
Action:
When doctors do operation under Halothanum apply it in an admixture with oxygen, make a careful premedication with atropine application. Thus the person practically passes a dyssociative stage and is almost nonpredatory disconnected (there is an oppression of the central excitatory system). The aspiration of pure Halothanum is absolutely another. Psychoawake action of Halothanum is similar to similar action of toluene.
Before the beginning of carrying out of a narcosis Halothanum it is necessary to make a premedication atropine. Halothanum inhalation carry out both with oxygen, and with an admixture of nitrous oxide with oxygen. For an introduction narcosis concentration of steams of Halothanum in an admixture routinely does not exceed 3 about. %. At purely inhalation introduction narcosis the surgical grade of anaesthesia is reached routinely in 4-6 minutes. After achievement of desirable depth of a narcosis concentration of Halothanum reduce. For maintenance of depth of a narcosis concentration of Halothanum from 0.5 to 1.5 is required about. %. The augmentation of depth of a narcosis during operation should be made by means of slow strengthening of Halothanum (in order to avoid undesirable falling of a BP).
Halothanum good anaesthetic, but a weak analgetic.
At utilisation of Halothanum the consciousness is switched off routinely in 1-2 minutes after has begun aspirations of its steams. In 3-5 minutes there comes a surgical grade of anaesthesia. Later 3-5 minutes after a stopping delivery of Ftorotanum patients start to clear up. Narcotic depression completely disappears in 5-10 minutes after short-term and in 30-40 minutes after a long narcosis. Excitation is observed seldom and expressed weakly.
Halothanum has running down an effect. Quenches sympathetic ganglions, invokes dilating of veins in a skin and muscles. Raises a vagus nerve tonus, invoking a bradycardia. Reduces an ophthalmotonus. Direct impact on a myocardium makes, reduces a systolic volume and contractility of a myocardium, raises sensitivity of a myocardium to catecholamins. Halothanum does not stimulate respiratory tracts; does not enlarge secretion of a saliva and allocation of a bronchial secret; some broncholitic an effect has. Oppresses vomitive jerks.