Metamphetaminum action
At Metamphetaminum application (the screw, Pervitinum) the inflow of forces, euphoria, a never-ending torrent of the thoughts quickly changing each other, an appetite total absence is felt. At a series of injections the subsequent long sleep is characteristic. Among negative effects excrete stereotypicalness of thinking (”cycling”), an anorexia, disturbances of regulation of cardiovascular system, atactic thinking. In comparison with the proximate analogue – an amphetamine – Pervitinum action is longer and invokes smaller euphoria. Euphoria of Pervitinum synthesised from drugs at intravenous application bind to reaction by-products (as a rule, iodine-pervitinom).
In optimum doses takes out sense of weariness, invokes an inflow of forces, raises working capacity, reduces appetite, relaxs and shortens action of hypnagogues. Possesses the expressed peripheric activity (narrows peripheric pots, raises arterial pressure). Pervitinum possesses direct adrenergic action on the central excitatory system, including on a reticular formation and some subcortical frames. Also slightly oppresses activity of a monoaminoxidase, protecting, thus, adrenaline and Noradrenalinum from decomposing. Under other data Pervitinum promoting effect is bound to selective inhibition of return seizure of Dopaminum; inhibition of activity MAO slightly, however Pervitinum is weakly subject to an oxidative deamination the yielded ferment (in comparison with Phenaminum) thanking N-metilnoj to bunch.
At the long use invokes insuperable mental dependence, especially in case of intravenous introduction by the drug prepared from an ephedrine. The withdrawal is expressed weakly. Use relapses frequent. 90 % of narcomaniacs applying it get nonperishable alienations (an aphrenia, paranoid exhibitings, motorial distresses, etc.)
A cute effects of Pervitinum.
Owing to that Pervitinum method is an intravenous injection, “arrival” and intoxication come very quickly, in some secs after a nyxis. From Pervitinum narcomaniacs describe “arrival” as the warm, pleasant wave covering all body which lasts all some secs, then there comes intoxication. Sensations from intoxication are described as an energy inflow, clearness of a head.
The raised state of spirit lasts about an hour, then there comes droop: «the Perfect world as though turns out on a wrong side. All around gradually dies away. The body is poured by gravity and weariness. It is impossible to move neither arms, nor feet, they weigh as wattle fences and do not wish to obey. At this time it is better to be one as if nearby someone is from it threat proceeds, you hate it… This sensation of an early beast… In this state you can give everything, everything, everything, everything for the following dose of the screw. Very much it would be desirable to return the celebratory world…»
After the terminal of intoxication to the person not probably to fall asleep, it would not be desirable to drink not is.
The main difference between Pervitinum and other psychostimulants consists that is a narcotic self-made.
Chemical in its contents is initially polluted, and the dose is selected by eye. Therefore aggression, suicides and insanity attacks at its method meet more often, than at method of “firm” amphetamines.
Chronic effects of Pervitinum.
Soon after the first experiments with Pervitinum, it becomes more narrow in some months of its regular method is necessary to the person easier to feel normal.
«Quickly enough you start to perceive – to retry high of the first dose will not be possible never. From pleasure there is only a short arrival… But you continue to be pricked, because without the screw a nightmare… I could lie only on a sofa – weeks. You can not do anything, desires are not present any, there are no forces even to rise and bread to buy. You are pricked, somehow by inertia to feel normal…
It is necessary to cheer up somehow…»
The pervitinovyj narcomaniac, except direct threat of development of madness as a result of direct chemical action of a narcotic on a brain, constantly is under the threat of a psychosis as a result of errors or conscious criminal acts of the manufacturer of a narcotic.
“Screw” narcomaniacs from the first till last days Pervitinum method constantly should test consequences of conscious and irresponsible errors which are supposed by underground “chemists” in the course of narcotic manufacturing.
Such sensations narcomaniacs scornfully name side effects, or nearly so normal “redoses”.
The person starts to endure the seasons of a dropsy of a brain, own madness invoked by a venenating of the excitatory system, as some “adventure” – a certain panel extraordinary new and consequently interesting impressions.
The science knows that the human brain can endure a similar edema the circumscribed quantity of times. More often without rendering of the specialised help the young man dies during 5-6th expressed psychosis.
Similar episodes arise and at method of other psychostimulants. But also in that, and in case of the latter they occur after enough long season of constant method of a narcotic.
At cocaine aspiration through a nose threat of development of a psychosis comes at the majority of narcomaniacs not earlier than in a year of regular method of a narcotic. Other business Pervitinum.
At the young man who uses these narcotics, such states can arise and arise at any moment of the use of a self-made psychostimulant, since the very first injection.